The immune system plays a crucial role in the success of pregnancy. Several specific immunological factors associated with reproductive failures and their study proved important in setting the correct diagnosis and appropriate therapeutic approach. Each of the subgroups of patients with reproductive problems (unexplained infertility, miscarriages, repeated IVF failures) have their specificity in the diagnosis and prevalence of one or other abnormal factors. While most of the mechanisms by which abnormal immunological results causing reproductive failure remain to be examined, these results can be used as markers for selection of treatment of the relevant reproductive problem.
- 1. Diagnostic and consultative work in the field of reproductive endocrinology and immunology in order to clarify cases of unexplained infertility, miscarriages and failed IVF procedures.
- 2. Immunotherapy in cases of reproductive failures.
- 3. Specialized laboratory immunodiagnostics.
- 4. Rating of the implantation of “competence” of the embryos in the embryo transfer.
One of the leading pathological symptoms in women with reproductive failure is associated with the so called “Killer cells” – NK cells. With these women, the problem of NK cells can be increased both in number and in their abnormal functional activity, as two factors can, and often are independent of one another, the average number may be an abnormal activity, and vice versa.
The analysis of NK cell activity is of great clinical importance, not only because of its predictive role in the success of the IVF procedure and outcome of pregnancy, but also for monitoring the effectiveness of the immunotherapy.
Immune induction of the blocking factors
In some cases, reproductive failure in women (women with recurrent miscarriages, failed IVF attempts, unexplained infertility, etc.) Are due to a problem in formation etc. “Blocking factors / antibodies.” They are necessary for normal Immunodeficiency recognition and immunomodulation in implantation of the embryo and the course of pregnancy. This type of therapy allows the mother’s immune system to form these factors through external stimulation.
The absence or presence of “blocking factors” were examined by a specific test, the result of which determines the application and frequency at the time of this type of therapy during pregnancy. The effectiveness of treatment is increased many times if the first test and therapy be made before the planned pregnancy.
The rating of implantation of “competence” of embryos in embryo transfer.
Only a developing embryo secrete products that alert the mother for the upcoming implantation. We examine these products in addition to the morphological assessment, increase the chance of selecting the most suitable embryos for transfer.